The Kragelund lab focuses on how structural disorder expands the molecular communication toolbox in biology and helps rethink protein interaction in the realm of structural disorder. One facet of the complexity of life is the cascade of signaling caused by thousands of proteins transferring unambiguous signals that instantly will regulate production and activities in the cell at the molecular level. Signal transfer initiated at the membrane is completed in the nucleus by the action of transcription factors and is conveyed through protein-protein interactions involving disordered regions. The PhD student will investigate the order-disorder cross-talk in the context of full-length transcription factors and how this cross-talk mediates regulation of transcription. By application of NMR spectroscopy and a suite of biophysical techniques we seek to map mechanisms of disorder-order crosstalk in transcription factors.