Aims of IDPro
The project "Intrinsically disordered proteins in health and disease" aims to deepen our understanding of the molecular principles that govern interactions and regulatory mechanisms within cellular networks—specifically through the lens of intrinsically disordered proteins (IDPs). These elusive yet vital molecules play critical roles in both health and disease, and they hold promise for future drug discovery efforts.
We have identified three pivotal research areas that will advance the field. These form the basis of our scientific work packages (WPs), each addressing a distinct yet interconnected aspect of IDP biology.
Motifs, Mechanisms, and Evolution
Exploring the building blocks and evolutionary trajectories of IDP function.
The Role of Context in IDP Binding and Function
Investigating how environments shape IDP interactions.
Targeting Cellular Networks
Leveraging our insights to develop strategies for drug targeting in models of human diseases, including cancer, neurodegenerative disorders, and viral infections.
The doctoral candidates (DCs) will be trained to harness state-of-the-art experimental and computational methods, empowering them to illuminate the molecular underpinnings of disease and identify new therapeutic opportunities. This foundational research will serve as a springboard for innovation in drug development.Complementing the scientific efforts are dedicated work packages for training, management, and dissemination—ensuring a comprehensive, supportive environment for the next generation of researchers.