The Jensen lab focuses on revealing the molecular mechanisms that underpin the function of large intrinsically disordered scaffold proteins in cell signaling. We study the structural and dynamic basis of how scaffold proteins recruit kinases and GTPases, how signaling information is transferred across scaffolding complexes and how the assembly of these complexes are regulated by post-translational modifications. The main experimental technique used in the lab is nuclear magnetic resonance (NMR) spectroscopy that is combined with X-ray crystallography and biophysical measurements of protein-protein interactions. The Ph.D. student will study two scaffold proteins within the JNK signaling pathway at atomic resolution and investigate how these scaffolds mutually cooperate to convey signaling specificity.